Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc14.6 | Oral Communications 14: Late Breaking | ECE2022

Engaging the Endocannabinoid System in Neuroendocrine Neoplasms (NENs) potentiates treatment outcomes and null drug resistance

Avniel- Polak Shani , Polak David , Oleinikov Kira , Gross David J , Wald Ori , Izhar Uzi , Mazeh Haggi , Drier Yotam , Glasberg Simona

Introduction: Patients with unresectable NENs are offered a variety of non-curable therapeutic options, which eventually fail due to drug resistance. Increasing evidence suggest an anticancer trait of cannabinoids, via cellular pathways including mTOR, known to be associated with drug resistance development. Still, limited data exist on the anti-cancer effects of cannabinoids in NENs.Aims: To understand the possible anti-tumor role of the cannabinoids an...